Visual-auditory visualisation of dynamic multi-scale heterogeneous objects.

The multi-scale phenomena analysis is an area of active research that is connecting simulations with experiments to get a correct insight into the compound dynamic structure. Visualisation is a challenging task due to a large amount of data and a wide range of complex data representations. The analysis of dynamic multi-scale phenomena requires a combination of geometric modelling and rendering techniques for the analysis of the changes in the internal structure in the case of data coming from different sources of various nature. Moreover, the area often addresses the limitations of solely visual data representation and considers the introduction of other sensory stimuli as a well-known tool to enhance visual analysis. However, there is a lack of software tools allowing perform an advanced real-time analysis of heterogeneous phenomena properties. The hardware-accelerated volume rendering allows getting insight into the internal structure of complex multi-scale phenomena. The technique is convenient for detailed visual analysis and highlights the features of interest in complex structures and is an area of active research. However, the conventional volume visualisation is limited to the use of transfer functions that operate on homogeneous material and, as a result, does not provide flexibility in geometry and material distribution modelling that is crucial for the analysis of heterogeneous objects. Moreover, the extension to visual-auditory analysis emphasises the necessity to review the entire conventional volume visualisation pipeline. The multi-sensory feedback highly depends on the use of modern hardware and software advances for real-time modelling and evaluation. In this work, we explore the aspects of the design of visual-auditory pipelines for the analysis of dynamic multi-scale properties of heterogeneous objects that can allow overcoming well-known problems of complex representations solely visual analysis. We consider the similarities between light and sound propagation as a solution to the problem. The approach benefits from a combination of GPU accelerated ray-casting, geometry, optical and auditory properties modelling. We discuss how the modern GPU techniques application in those areas allows introducing a unified approach to the visual-auditory analysis of dynamic multi-scale heterogeneous objects. Similarly to the conventional volume rendering technique based on light propagation, we model auditory feedback as a result of initial impulse propagation through 3D space and its digital representation as a sampled sound wave obtained with the ray-casting procedure. The auditory stimuli can complement visual ones in the analysis of the dynamic multi-scale heterogeneous object. We propose a framework that facilitates the design of dynamic multi-scale heterogeneous objects visual-auditory pipeline and discuss the framework application for two case studies. The first is a molecular phenomena study that is a result of molecular dynamics simulation and quantum simulation. The second explores microstructures in digital fabrication with an arbitrary irregular lattice structure. For considered case studies, the visual-auditory techniques facilitate the interactive analysis of both spatial structure and internal multi-scale properties of volume nature in complex heterogeneous objects. A GPU-accelerated framework for visual-auditory analysis of heterogeneous objects can be applied and extend beyond this research. Thus, to specify the main direction of such extension from the point of view of the potential users, strengthen the value of this research as well as to evaluate the vision of the application of the techniques described above, we carry out a preliminary evaluation. The user study aims to compare our expectations on the visual-auditory approach with the views of the potential users of this system if it is implemented as a software product. A preliminary evaluation study was carried out with limitations imposed by 2020/2021 restrictions. However, it confirms that the main direction for the visual-auditory analysis of heterogeneous objects has been identified correctly and visual and auditory stimuli can complement each other in the analysis of both volume and spatial distribution properties of heterogeneous phenomena. The user reviews also highlight the necessary enhancements that should be introduced to the approach in terms of the design of more complex user interfaces and consideration of additional application cases. To provide a more detailed picture on evaluation results and recommendations introduced, we also identify the key factors that define the user vision of the approach further enhancement and its possible application areas, such as users experience in the area of complex physical phenomena analysis or multi-sensory area. The discussed in this work aspects of heterogeneous objects analysis task, theoretical and practical solutions allow considering the application, further development and enhancement of the results in multidisciplinary areas of GPU accelerated High-performance visualisation pipelines design and multi-sensory analysis

Advancing Creative Visual Thinking with Constructive Function-based Modelling.

Modern education technologies are destined to reflect the realities of a modern digital age. The juxtaposition of real and synthetic (computer-generated) worlds as well as a greater emphasis on visual dimension are especially important characteristics that have to be taken into account in learning and teaching. We describe the ways in which an approach to constructive shape modelling can be used to advancing creative visual thinking in artistic and technical education. This approach assumes the use of a simple programming language or interactive software tools for creating a shape model, generating its images, and finally fabricating a real object of that model. It can be considered an educational technology suitable not only for children and students but also for researchers, artists, and designers. The corresponding modelling language and software tools are being developed within an international HyperFun Project. These tools are easy to use by students of different age, specialization and abilities, and can easily be extended and adapted for various educational purposes in different areas

Multisensory analytics for several interconnected scalar fields analysis

In our day it's hard to imagine modern research in sophisticated scientific area without use of visual analytics tools. However, humans are able to receive and analyze information about world around them not only through their eyes, but with help of other sensory stimuli as well and there is no reason why scientific data analyses should be an exception. As a result, there is a lot of research done recently in area of multimodal interfaces that are characterized by various sensory stimuli involvement and especially in visual-auditory interfaces development. In this work we introduce multisensory analytics approach, discuss theoretical issues, introduce main concepts of software tools implementing our approach, describe one of the possible auditory-visual mappings methods for particular case of scalar fields analyses - simultaneous interconnected scalar fields analyses and give practical examples

Visual-auditory Volume Rendering of Dynamic Quantum Chemistry Molecular Fields.

This work deals with a visual-auditory visualisation of dynamic heterogeneous objects represented by continuous scalar fields obtained from quantum chemistry. The research concentrates on complex phenomena modelling and rendering aspects and takes advantage of GPU implementation. The approach uses the constructive HyperVolume for the multi-scale representation of the molecular phenomena. To propose an approach to the visual-auditory rendering, we adapt the real-time interactive volume ray-casting to compute the optical and auditory properties. We demonstrate the approach application for the visual-auditory rendering of dynamic molecular structures

Thermal stability of brushite with chitosan samples

In this paper, the powders of brushite from an aqueous solution of Ca(NO[3])[2]- (NH[4])[2]HPO[4] with different content of chitosan were synthesized. XRD data revealed that all samples are single-phase and are brushite (CaHPO[4]•centerdot2H[2]O). By FT-IR spectroscopy and BET methods, it was found that chitosan adsorbs onto the surface of powders. With increase of the content of the additive, the average size of crystallites increases 4.0 – 4.8 – 11.8 [mu]m, respectively, and the dissolution rate in isotonic solution also decreases. The thermal stability of the composite powders was studied. It was established that the highest destruction of samples occurs in the range 473-673 K by removing of adsorption and crystallization water and partial change of the structure of the mineral and chitosan. At a temperature of 873 K, carbonization of the organic additive occurs

Delayed neurological maturation is a cause for distress during fetal growth restriction

Theory of fetal programming contributes to a better understanding of the relationship of many human diseases with antenatal period pathology. Regulatory impact of nervous system is of great importance. Fetal growth restriction (FGR) is a convenient model for investigation of the abnormalities of fetal neurodevelopment. Fetal heart rate variability is a well-known approach for fetal autonomic function detection. The aim of the study was to detect several patterns of autonomic nervous regulation in FGR complicated by fetal distress or without fetal distress. Materials and methods. Totally 64 patients at 26–28 weeks of gestation were enrolled. 23 patients had normal fetal growth and were included in the Group I (control). 20 pregnant women with FGR without fetal distress were observed in Group II. 21 patients with FGR and fetal distress were included in Group III. Fetal heart rate variability and conventional cardiotocographic patterns were obtained from the RR-interval time series registered from the maternal abdominal wall via non-invasive fetal electrocardiography. Results. Suppression of the total level of heart rate variability with sympathetic overactivity was found in FGR. The maximal growth of sympathovagal balance was found in Group III. Fetal deterioration was associated with an increased quantity of decelerations, reduced level of accelerations, and decreased of short term variations and low term variations. But a decelerative pattern before 26 weeks of gestation was normal. Therefore fetal autonomic malfunction could be a result of persistent neurological immaturity in FGR. The approach based on the monitoring of fetal autonomic maturity in the diagnosing of its well-being should be tested in further studies. Conclusion. Fetal heart rate variability variables and beat-to-beat variations parameters could be the sensitive markers of neurological maturation and good predictors for fetal deterioration

AI MENTORING AS A FORM AKMEOLOGICHESKOJ ORIENTED PROFESSIONAL INTERACTION

Optimization of professional relationships in the "mentor- apprentice" promotes the formation of a professional orientation akmeologicheskoj both subjects interaction. On the one hand , mentoring is one of the oldest and most effective ways to acquire knowledge and skills of young employees of the company in the process of adapting to a new team . On the other - allows teacher to identify their professional and personal opportunities and consciously decide to choose the optimum time of interaction with the students, based on their individual characteristics, as well as improve their own skills.Оптимизация профессиональных взаимоотношений в системе «наставник – ученик» способствует формированию акмеологической профессиональной направленности у обоих субъектов взаимодействия. Наставничество является одним из самых старых и эффективных способов приобретения знаний и навыков молодыми сотрудниками предприятия в процессе их адаптации в новом коллективе; позволяет наставнику выявить свои профессионально-личностные возможности и осознанно определиться в выборе оптимального стажа взаимодействия с учениками, с учетом их индивидуальных особенностей, а также повысить уровень собственного мастерства

Selection of cultivation medium for production of late stationary phase serine proteinases from Bacillus intermedius

B. intermedius have been shown previously to secrete two serine proteinases: glutamyl endopeptidase 2 and subtilisin 2 during the late stationary phase, with maximal levels of the enzymes activities recorded at the 40th and 44th hours of growth, respectively. In the current study, we analyzed the impact of various culture medium components on biosynthesis of these proteinases. Yeast extract and gelatin did not stimulate the enzymes biosynthesis. However, on the medium containing 0.1% casein subtilisin 2 production increased to reach 140%. Biosynthesis of both serine proteinases, produced by B. intermedius at the late stationary phase, were found to be inhibited by individual amino acids, and to be insensitive to catabolite repression. In order to maximise enzyme production, the presence of Ca 2+ and Mg2+ at concentration of 5 mM was shown to be necessary. Based on the results of this work, the composition of a complex culture media for the effective production of late stationary phase proteinases by B. intermedius was developed

Analysis of sociohygienic indicators and assessment of the quality of life of patients with hypertension

The article deals questions of the quality of life of patients with hypertension and almost healthy people and an analysis of the social and hygienic indicators of population groups.В статье рассмотрены вопросы качества жизни пациентов с гипертонической болезнью и почти здоровых людей и проведен анализ социально – гигиенических показателей групп населения

Defining Satisfactory Methods of Treatment in Rare Diseases When Evaluating Significant Benefit-The EU Regulator's Perspective

Since the implementation of the EU Orphan Regulation in 2000, the Committee for Orphan Medicinal Products at the European Medicines Agency has been evaluating the benefits of proposed orphan medicines vs. satisfactory treatment methods. This type of evaluation is foreseen in the Orphan Regulation as the orphan designation criterion called the "significant benefit." In this article, based on 20 years of experience, we provide a commentary explaining what is considered a satisfactory method of treatment in the context of the EU Orphan Regulation and for the purpose of the assessment of significant benefit. We discuss the challenges posed by continuously changing clinical practise, which is associated with the increasing number of treatment options, evolving nature of medicinal therapeutic indications and our understanding of them